There is an interesting article in the December issue of Scientific American entitled "Smarter Uses of Nuclear Waste" (p.84) that describes a nuclear infrastructure that uses liquid metal cooled fast reactors and local (plant level) recycling of spent fuel using a system called "pyrometallurgy" to process and fabricate fresh fuel loads.

What is interesting with this setup is that it can be tuned (apparently) to be a net consumer of fissile isotopes by downblending, and then later the system can be adjusted to actually burn fissionable (not fissile) isotopes such as U-238 (found in depleted uranium) to produce additional energy. Spent fuel is recycled by using an adaptation of electrorefining to remove fission products while retaining most of the actinides (I'm not sure of the chemistry--I'm sure some specific tweaking has to be done to get this right...) Also interestingly the fuel is actually used in metallic form--intersting because this is not the typical method used for reactors. The coolant is either liquid sodium or lead/bismuth.

By seperating out the fission products, a much higher proportion of the fuel energy can be utilized, and the fission products need only be stored for a couple of centuries before they decay back to the level of the source ore (a much more manageable task than the hundreds-of-thousands-of-years proposed for Yucca Mountain...)

I think it's also interesting because this could be a model for future extraplanetary nuclear infrastructure--for instance a lunar colonial nuclear infrastructure that uses minimal water or a Martian indigineous nuclear infrastructure.